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Area of Research
Biomechanics, tissue engineering, cellular mechanotransduction, bone
modeling and remodeling, and bone regeneration. Currently, we are
working on the anti-resorptive effect of mechanical loading on bone
tissue; the advanced microfluidics system for bone cell
mechanotransduction study; the role of focal adhesion assembly in cell
mechanosensitivity using micropatterned surface; and development of
advanced artificial bone matrix by employing novel microfabrication
technologies.
Professor You is jointly appointed with the Institute of Biomaterials and
Biomedical Engineering.
Selected Publications
Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler
(2004) Ultrastructure of the osteocytes process. Anatomical Record 278A(2): 505-513.
Lidan You, Stephen C. Cowin, Mitchell B. Schaffler, and Sheldon
Weinbaum (2001) Flow induced cytoskeletal strain amplification: Turning
up the strain in bone cells. Journal
of Biomechanics 34:1375 –1386.
Chi Hyun Kim, Lidan You, Clare E. Yellowley, Christopher R. Jacobs
(2006) Oscillatory fluid flow-induced shear stress decreases
osteoclastogenesis through RANKL and OPG signaling. Bone. 39: 1043-1047.
Lidan You, Sara Temiyasathit, Chihyun Kim, Padmaja Tummala, Wei Yao,
Wade Kingery, Christopher R. Jacobs (2007) Regulation of osteoclasts by
osteocytes under mechanical loading. Bone.
In press.
Open Positions
We are looking for graduate and undergraduate students for a number of
projects on bone cell mechanotransductions. Interested candidates
should contact Professor You.
Contact
Lidan You, Ph.D
5 King's College Road, Room 314D
Toronto, Ontario, Canada M5S 3G8
Tel: 416-978-5736
Fax: 416-978-7753
Email :
youlidan@mie.utoronto.ca
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